Expeditious Extraction of Histones from Limited Cells or Tissue Samples and Quantitative Top-Down Proteomic Analysis

Expeditious Extraction of Histones from Limited Cells or Tissue Samples and Quantitative Top-Down Proteomic Analysis

Histones are the first protein element of chromatin and are concerned in just about all DNA-templated processes. Histones are abundantly post-translationally modified by quite a lot of chromatin-modifying equipment. These post-translational modifications (PTMs) are acknowledged by a variety of “reader” proteins, which recruit further proteins to particular places on chromatin and impart exact and...